Abstract: Although cyclosporine and antibiotics have been widely used in clinical for immune suppressing in organ transplantation and antimicrobial in bacterial infection respectively, but their effects on CD4⁺ and CD8⁺ lymphocytes infiltration in myocardium have been unknown. In the present study we accounted CD4⁺ and CD8⁺ lymphocytes by immuno-histochemistry, in myocardium of rats which had separately orally administrated with cyclosporine and antibiotic and selenium for 24 h, and compared to the control group. Results showed that both of CD4⁺ and CD8⁺ lymphocytes accounts were significantly decreased(P<0.01)in three experimental groups than the control. The cell accountings towards cyclosporine were lower than antibiotics and lower than selenium. These data suggest that all of cyclosporine and antibiotics and selenium evidently suppress CD4⁺ and CD8⁺ lymphocytes infiltration in myocardium, and display a different suppressing.

Key words: cyclosporine, antibiotics, selenium, lymphocyte