Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6

Journal of Capital Medical University ›› 2003, Vol. 24 ›› Issue (1): 11-13.

• 论著·基础研究 • Previous Articles Next Articles

Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6

Shen Haizhong¹, Zhang Liping¹, Ping Guoling¹, Zhang Hongchun¹, Jing Xuefang¹, Li Yuying¹, Li Yulan¹, Li Weihong², Zhang Haiyan²

1. Department of Immunology, Capital University of Medical Sciences;2. Department of Cell Biology, Capital University of Medical Sciences

Received:2002-07-14 Revised:1900-01-01 Online:2003-01-15 Published:2003-01-15

Abstract

Abstract: To evaluate the effect of Streptococcus HlpA on interlukin-6(IL-6)production by murine peritoneal MΦ, HlpA and/or LTA were added to the cultured MΦ and maintained for different time periods. IL-6 activity was measured by means of 7TD1 cells. The results showed that the IL-6 production from MΦ induced by HlpA of Streptococcus was time and concentration dependent in vitro. There was a synergisticly increased response on the production of IL-6 induced by the mixture of HlpA and LTA, as compared to HlpA alone. On the contrary, the addition of heparin could deduce the IL-6 production.

Key words: Streptococcus, macrophage, interlukin-6

CLC Number:

R378.1⁺2

Shen Haizhong;Zhang Liping;Ping Guoling;Zhang Hongchun;Jing Xuefang;Li Yuying;Li Yulan;Li Weihong;Zhang Haiyan. Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6[J]. Journal of Capital Medical University, 2003, 24(1): 11-13.

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Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6

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