Journal of Capital Medical University ›› 2003, Vol. 24 ›› Issue (1): 19-22.

• 论著·基础研究 • Previous Articles     Next Articles

Effect of Chinese Herb on NOS Expression in Dorsal Root Ganglia in Rats with Spinal Cord Hemisection

Ma Yuping1, Gao Xiulai1, Chen Yaliang1, Lu Tao1, Song Yizhi1, Jing Peng1, Han Fengyue2, Su Jing2, Liu Weidong2, Zhang Ping2, Chang Chaoying2, Liu En2   

  1. 1. Department of Anatomy, Capital University of Medical Sciences;2. Institute of Orthopaedics and Traumatology, China Academy of TCM
  • Received:2002-12-27 Revised:1900-01-01 Online:2003-01-15 Published:2003-01-15

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Abstract: The object was to study the effect of Chinese Herb I(SCI) on NOSexpression in dorsal root ganglia (DRG) in rats with spinal cord hemisection and to explore the mechanism of spinal cord regeneration promoted by SCI. NADPH-d histochemical method and image analyses were used to detect changes of NOS, which was evoked by spinal injury in Wistar rats. The result indicated that evoking NOS was strengthened by the administration of SCI as compared with that of the control group. The up regulation of NOS was heightened continuously in DRG of the injury side and the strong positive findings nearly exceeded 40%. This study shows that the magnitude of NOSis associated with spinal regeneration and repair, and SCI can regulate NOS expression and promote regeneration of the spinal cord.

Key words: SCI, spinal regeneration and repair, dorsal root ganglia, nitricoxide synthase

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