Relationship between Glycosylated Low Density Lipoprotein and Coronary Artery Disease

Abstract

Abstract: The objective of the study was to observe the changes of glycosylated low density lipoprotein (Gly-LDL) in patients with coronary artery disease (CAD) and in patients with CADcomplicated type-2 diabetes mellitus. The levels of Gly-LDL index were measured by nitroblue tetrazolium reduction technique in sixty eight patients with CAD. Among patients with CAD, there were twenty eight patients with type 2 diabetes mellitus and forty patients without diabetes mellitus. The levels of Gly-LDL index were significantly higher in patients with CAD than those without CAD (P< 0.01). Among the CAD group, the levels of Gly-LDL index were higher in patients with type-2 diabetes mellitus than those in patients without diabetes mellitus (P<0.05). The result indicates the levels of Gly-LDL index increase in patients with CAD and they have a significant increase in patients with CAD complicated type-2 diabetics. Gly-LDL may be one cause of the accelerated atherogenesis in type-2 diabetic patients and may be indirect biochemical marker of the development of macroangiopathy in type-2 diabetic patient.

Key words: coronary artery disease, diabetes mellitus, glycosylated low density lipoprotein

CLC Number:

R541.4

Wang Qing;Hu Dayi;Wang Jieping;Yin Zhaoxia. Relationship between Glycosylated Low Density Lipoprotein and Coronary Artery Disease[J]. Journal of Capital Medical University, 2003, 24(1): 47-50.

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Relationship between Glycosylated Low Density Lipoprotein and Coronary Artery Disease

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