Relationship between Endothelial Nitric Oxide Synthase 4b/a Gene Polymorphism and Curative Effects of Valsartan in Hypertensive Patients

Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (3): 349-352.

• 论著·临床研究 • Previous Articles Next Articles

Relationship between Endothelial Nitric Oxide Synthase 4b/a Gene Polymorphism and Curative Effects of Valsartan in Hypertensive Patients

Hua Qi¹, Li Dongbao¹, Zou Haiqiang², Chen Biao², Pi Lin¹, Liu Rongkun¹

1. Department of Cardiology, Xuanwu Hospital, Capital University of Medical Sciences;2. The Beijing Institute of Geriatrics

Received:2003-09-11 Revised:1900-01-01 Online:2004-07-15 Published:2004-07-15

Abstract

Abstract: To investigate the response of patients with different endothelial nitric oxide synthase(eNOS) genotype (4b/a)to the treatment of angiotensin Ⅱ type 1 receptor antagonist (valsartan), 72 patients with hypertension were divided into two groups according to eNOS gene 4b/a polymorphism: aa+ab group (n=16)and bb group (n=56).All patients were treated with valsartan for 4 weeks and their blood pressure were measured.Effective rate of valsartan antihypertension in aa+ab group was 93.8%, but the effective rate in bb group was 64.3%.Curative effects of valsartan was significantly higher in aa+ab group than in bb group.It is suggested that eNOS 4b/a gene polymorphism can be used as one of adjustive indicators for predicting the effects of using angiotensin Ⅱ type 1 receptor antagonist in treatment of hypertensive patients.

Key words: gene polymorphism, angiotensin Ⅱ type 1 receptor antagonist, hypertension, response to treatment

CLC Number:

R544.1

Hua Qi;Li Dongbao;Zou Haiqiang;Chen Biao;Pi Lin;Liu Rongkun. Relationship between Endothelial Nitric Oxide Synthase 4b/a Gene Polymorphism and Curative Effects of Valsartan in Hypertensive Patients[J]. Journal of Capital Medical University, 2004, 25(3): 349-352.

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Relationship between Endothelial Nitric Oxide Synthase 4b/a Gene Polymorphism and Curative Effects of Valsartan in Hypertensive Patients

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