Abstract: The aim was to investigate the effects of antihypertension and reverse left ventricular hypertrophy by carvedilol or bisoprolol in patients with mild to moderate essential hypertension.The forty cases of mild to moderate essential hypertension were selected for this random single-blind, paralleling controlled clinical study.Patients were randomized to take 12.5～25 mg carvedilol tablet once daily or bisoprolol 2.5～5 mg once daily if DBP was still in the range of 12.0～14.6 kPa(90～110 mmHg) after 2 week placebo baseline.Carvedilol group included 20 cases, Bisoprolol group included 20 cases, The course was 24 weeks, Blood pressure and heart rate were measured and symptoms and signs were recorded.At the end of placebo and in 24 weeks examined heart ultrasound, blood routine, serum glucose, blood lipid, hepatic function and renal function.SBP, DBP and heart rate of patients in two groups decreased obviously.There were significant differences between the two groups.Ventricular hypertrophy of carvedilol group improved than pretherapy.There were significant differences between the two groups.Carvedilol was well-tolerated with less side effects that concluded mild headache, tiredness, dizziness, slightly elevating of serum Glucose.Carvedilol can well treat the mild moderate essential hypertension effectively and safely by 12.5～25 mg once daily.

Key words: carvedilol, bisoprolol, essential hypertension, left ventricular hypertrophy