Effect of Intraoperative Continuous Nimodipine Infusion on Systemic Hemodynamics in Aneurysm Surgery

Abstract

Abstract: The aim of this study was to evaluate the effect of intraoperative continuous nimodipine infusion on systemic hemodynamics in intracranial aneurysm surgery.Thirty consecutive patients undergoing intracranial aneurysmal surgery without a preexisting cerebral ischemia were prospectively randomized into one of two groups: Isoflurane maintained anesthesia (group A, n=15) and nimodipine + isoflurane maintained anesthesia (group B, n=15).The patients in group B were given nimodipine infusion continuously 20 μg/(kg·h) after induction of anesthesia and anesthetized with 1 MAC isoflurane.The patients in group A were maintained with 1 MAC isoflurane anesthesia during the whole procedure.Systemic hemodynamics were monitored intraoperatively.Mean arterial pressure (MAP) were lower significantly in group B than that in group A, but MAP were kept in clinical safe range.Heart rates were kept stable.However, cardiac output, cardiac index, myocardial contract acceleration increased significantly in group B, and systemic vascular resistance decreased after nimodipine infused.Conclusion: Systemic hemodynamics during intraoperative continuous nimodipine 20 μg/(kg·h) infusion combined with 1 MAC isoflurane anesthesia are in clinical safe range.

Key words: aneurysm, doppler, isoflurane, nimodipine

CLC Number:

Han Ruquan;Lu Zheng;Wang Baoguo;Wang Enzhen;Wang Shuo;Zhao Jizong. Effect of Intraoperative Continuous Nimodipine Infusion on Systemic Hemodynamics in Aneurysm Surgery[J]. Journal of Capital Medical University, 2004, 25(3): 383-386.

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Effect of Intraoperative Continuous Nimodipine Infusion on Systemic Hemodynamics in Aneurysm Surgery

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