Abstract: The aim was to investigate the single nucleotide polymorphism(SNP) of the novel hyperplasia suppressor gene (HSG) and uncover the relationship of HSG SNP and hypertension. Altogether 74 normaltensive people (male 38, female 36), 51 essential hypertensive patients(male 27, female 24),which came from the outward patients of Anzhen hospital, and 20 patients of hypertension with family history (male 9, female 11) were chosen. Respectively, the average age was 54.15±7.77, 57.25±7.97 and 49.97±6.93. Patients vein blood was drawn and DNA was extracted, then the right primers and PCR were designed. The sequences of each PCR-product were sequenced by ABI PRISM 377-DNA sequencer. Cr and BUN were high in hypertensive patients than in normaltensive patients (P<0.01).The level of AngⅡ, ET were higher significantly in normaltensive(P<0.01, P<0.01) while ANP and CGRP were lower in hypertensive patients than in moraltensive patients(P<0.05, P<0.01), though no obvious differences existed in hypertensive patients with family history and the normal control group. Systolic pressure was closely related to age (R=0.387;P<0.001). Diastolic pressure was positively related to AngⅡ,Cr,BUN(R=0.328,0.289,0.165;P<0.001),though was negatively related to HDLC(R= -0.149,P<0.01) There was obvious difference in the 140 nucleotide of the 12th intron nucleotide of HSG in normaltensive, hypertensive patients and patients with family history (0.80,0.41,0;P< 0.001). Probably, Cr and BUN were a sign of hypertension and its complication. Some vasoactive factors may be important in the origin and development of primary hypertension. There was a G-deletion SNP of 12th intron nucleotide of HSG in Chinese, and perhaps the SNP was an independent risk factor for hypertension.

Key words: hypertension, HSG, vasoactive factor, single nucleotide polymorphism