Abstract:

Objective The study was designed to investigate the clinical characteristics of aspirin resistance in patients with cardiovascular diseases.Methods 326 patients with stable cardiovascular diseases were evaluated for aspirin resistance with idetection of optical platelet aggregation induced by arachidonic acid(AA) and adenosine diphosphate(ADP). Aspirin resistance was defined as an average aggregation of over 20% with 0.5 mmol/L AAand over 70% with 10 μmol/L ADP. Aspirin semiresistance met one, but not both of the above criteria. Results 4.9% of the patients were aspirin resistant and 27.6% were aspirin-semiresistant. The clinical characteristics of aspirin resistant patients compared with aspirin sensitive patients were: 1) most of the aspirin-resistant patients were senile; 2) female patients were more frequent than male; 3) patients with diabetes were dominant in number; 4) it had nothing to do with hypertension, hyperlipodemia, red blood cell count, hemoglobin and platelet count; 5) it was relatively rare in smoking population. Conclusion The incidence of aspirin resistance is similar to other studies, in addition to aging and female gender, diabetes is also a risk factor in aspirin resistance.

Key words: cardiovascular diseases, aspirin, resistance