Abstract:

Objective To investigate the expression of collagen type Ⅰ and the effect of pancreatic cell in repairment of acute pancreatitis(AP). Methods NIH swiss rats were divided into two groups: one was the control, the other was acute pancreatitis. Acute pancreatitis were induced by intraperitoneal injection of cerulein. Routine pathological examination was used to evaluate the degree to pancreac inflammation,the expression of collagen type Ⅰ was detected by method of immunohistochemistry, and the proliferation of cell was examined by flow cytometry analysis. Results Intraperitoneal of cerulein injection could induce AP, it was the most serious duration of injury of pancreas that 8 h after cerulein injection and recovered seven days later. Expression of collagen type Ⅰ was increased in AP, and three stages of cell proliferation after APwas induced: the early active stage and the middle inhibitive stage; the last high stage. Conclusion APis a self-limited disease, which can be repaired by bodyself. Fibrosis of mesenchyma, increasing of expression of collagen type Ⅰ and proliferation of pancreatic cell play important role in the repairment of AP.

Key words: acute necrotizing pancreatitis, collagen type Ⅰ, repair