Abstract:

Objective To investigate the reasons of failure with mifepristone in ectopic pregnancy treatment, and find theoretical reference on receptor level for anti-progestogen pharmacal therapy in clinical ectopic pregnancy treatment. Methods All the selected cases were divided into three groups, the mifepristone treatment failure group, the operation group and the normal pregnancy group. The decidua reaction in all the groups were observed with HE staining under microscope. The expressions of ER and PR in fallopian tube wall of pregnancy site during tubal pregnancy were measured with immunohistochemical method. The failure cases of mifepristone treatment were also measured. Results The decidua reactions in the mifepristone treatment group and the operation group were less than that in the normal pregnancy(P<0.05). The expression of ER was of no significant difference among the three groups. The expression of PR in the mifepristone treatment failure group was less than in the operation group, while the expression of PR in the normal pregnancy group is more than in other two groups.Both the differences were significant. Conclusion It was noticed of a weak tubal tissue, less decidua reaction, and low expression of PR in tubal pregnancy. So, it was not theoretically reasonable for mifepristone treatment to tubal pregnancy which may have little target tissue of mifepristone.

Key words: ectopic pregnancy, fallopian tube, ER, PR, mifepristone