Abstract:

Objective To study the clinical value of Adenosine deaminase in cerebrospinal fluid and serum for the diagnosis of some neurogical diseases. Methods With Peroxidase assay to detect the Adenosine deaminase level in serum and cerebrospinal fluid in 201 cases of the neurological diseases(benign tumors, malignant cancer, multiple sclerosis, cerebral infarction, hydrocephaly, encephalic angiona, brain bemorrhage, spinal cord tumor, virus meningitis) as well as 24 normal persons. With t test or rank test to statistical analysis for the cases with neurological diseases which were divided into 9 groups and normal group. The cases of all neurological diseases groups were compared with each other. Results There was no significance for all the cases with adenosine deaminase level in serum from the neural disease. The adenosine deaminase levels in CSF from neurological diseases exception block in brain were significantly higher than those in normal group(P<0.01). There were statistic significances. Adenosine deaminase levels in CSF from malignant cancer group were higher than those in benign tumors group(P=0.037). Adenosine deaminase levels in CSF from multiple sclerosis were of statistic significances than those in spinal cord tumor, meningitis and cerebral hemorrhage(P<0.05). Conclusion Adenosine deaminase level in serum is of no significance in the diagnosis and identification. The determination of adenosine deaminase in cerebrospinal fluid is helpful in the diagnosis differentiation of some neurological diseases, but it is of no special significance in diagnosis.

Key words: serum, cerebrospinal fluid, adenosine deaminase, neural disease