Abstract: Objective To determine the incidence of depression and correlated factors in Parkinson's patients.Methods 117 Parkinson's patients were diagnosed and assessed using Self-rating Depression Scale(SDS) and Hamilton Depression Rating Scale(HAMD).The incidence,disease severity and correlated factors of depression were statistically analyzed,and a factor analysis was carried out on HAMD.Results The incidence of depression in Parkinson's patients was 43.6%,of which 88.2% were mild depression.Univariate analysis revealed that a high frequency of depression occurred in patients with bad economic status,long Parkinson's disease(PD) duration,high H&Y stage and Webster score.Depression was found to be only significantly correlated to disease status(the comparisons of Webster score had statistically significance) by means of Logistic regression analysis.According to each factor analysis of HAMD,the scores of cognitive impairment,tardiness,body anxiety and sleep disturbances of the patients with depressive syndromes were higher than that of non-depression patients(P≤0.001).No difference was noted with body weight loss.Conclusion PD patients have a high susceptibility to depression,and duration of PD and H&Y stage appear to be the strongest predictor of depression.

Key words: Parkinson's disease(PD), depression, HAMD