Abstract: Objective To evaluate the feasibility of inducing choroidal neovascularization(CNV)in C57BL/6Jmice by argon laser.Methods Twenty-eight C57BL/6Jmice were divided into 7 groups.In each group,the mice receieved retinal photocoagulation by argon laser in both eyes,at 2 hours,3,7,10,14,28 and 60 days after photocoagulation,the formation and nature process of CNVwere observed by fundus fluorescein angiography(FFA),and lightmicroscopy(LM).Results FFAand LMdemonstrated that CNVbegan to form at the seventh day after photocoagulation,increased at the tenth day,reached the peak at the twenty-eighth day and kept stable until sixty day.Conclusion Argon Laser can successfully induce CNVin C57BL/6Jmice,and it is an ideal animal model for further study.

Key words: argon laser, choroidal neovascularization, animal model