Abstract: Objective To study the effect of traditional Chinese medicine complex 912 for injection on the serum cytokine level of the multiple organ dysfunction syndrome(MODS) animal model. Methods Thirtytwo oneyearold male healthy piglets with body weight 20~25 kg were used for this study. Standard Escherichia coli(17 million/kg) was injected into right jugular vein slowly. Five hours after the injection all the animals developed MODS, and these MODS model animals were randomly divided into the following two groups: 912 complex treatment group and normal saline control group. Serum endotoxin and cytokines including tumor necrosis factor(TNF), interleukin1(IL1), interleukin6(IL6), interleukin10(IL10), and nitric oxide(NO) were determined at 1 h, 3 h, 5 h and 7 h after treatment. Results The serum cytokines decreased 3 h after treatment with 912 complex injection, and were lower than those of the normal saline control group at the same time points. Conclusion These finding provide the experimental basis for further study on treatment of MODS with traditional Chinese medicine 912 complex injection.

Key words: components 912 injection, multiple organ dysfunction syndrome, animal model, cytokines