Experimental Research on the Effects of a Traditional Chinese Medicine Complex 912 for Injection on Serum Cytokine Levels in the Multiple Organ Dysfunction Syndrome Animal Model

Journal of Capital Medical University ›› 2010, Vol. 31 ›› Issue (2): 251-254.

• 基础研究 • Previous Articles Next Articles

Experimental Research on the Effects of a Traditional Chinese Medicine Complex 912 for Injection on Serum Cytokine Levels in the Multiple Organ Dysfunction Syndrome Animal Model

REN Tian-hua¹, ZHANG Shu-wen^2*

1. Department of Emergency, Beijing Tiantan Hospital, Capital Medical University;2. Department of Infection and Critical Care, Beijing Friendship Hospital, Capital Medical University

Received:1900-01-01 Revised:1900-01-01 Online:2010-04-21 Published:2010-04-21
Contact: ZHANG Shu-wen

Abstract

Abstract: Objective To study the effect of traditional Chinese medicine complex 912 for injection on the serum cytokine level of the multiple organ dysfunction syndrome(MODS) animal model. Methods Thirtytwo oneyearold male healthy piglets with body weight 20~25 kg were used for this study. Standard Escherichia coli(17 million/kg) was injected into right jugular vein slowly. Five hours after the injection all the animals developed MODS, and these MODS model animals were randomly divided into the following two groups: 912 complex treatment group and normal saline control group. Serum endotoxin and cytokines including tumor necrosis factor(TNF), interleukin1(IL1), interleukin6(IL6), interleukin10(IL10), and nitric oxide(NO) were determined at 1 h, 3 h, 5 h and 7 h after treatment. Results The serum cytokines decreased 3 h after treatment with 912 complex injection, and were lower than those of the normal saline control group at the same time points. Conclusion These finding provide the experimental basis for further study on treatment of MODS with traditional Chinese medicine 912 complex injection.

Key words: components 912 injection, multiple organ dysfunction syndrome, animal model, cytokines

CLC Number:

R 632.9

REN Tian-hua;ZHANG Shu-wen. Experimental Research on the Effects of a Traditional Chinese Medicine Complex 912 for Injection on Serum Cytokine Levels in the Multiple Organ Dysfunction Syndrome Animal Model[J]. Journal of Capital Medical University, 2010, 31(2): 251-254.

[1]	Huang Qi, Zhou Yilun, Sun Xuefeng. Effect of shared peripheral circulation on renal injury in diabetic kidney disease mice [J]. Journal of Capital Medical University, 2022, 43(5): 674-679.
[2]	Zhang Xinhong, Yang Chuqi, Wang Xuan, Shen Xiaguang, Fang Chun, Wang Fengying. Correlation of interleukin-6 and hypersensitive C-reactive protein with cerebral venous and sinus thrombosis in perinatal stage [J]. Journal of Capital Medical University, 2021, 42(2): 210-213.
[3]	Wang Yuqing, Chen Zhigang, Li Fangfang, Zhang Sijia, Luo Yumin, Zhao Haiping. Changes of Pbk and its correlation with cytokine IGF-1 in glial cells after oxygen and glucose deprivation [J]. Journal of Capital Medical University, 2021, 42(2): 251-256.
[4]	Zhang Chen, Liu Zige, Song Guorui, Li Yan, Chen Desheng, Cheng Mengqi. Morphological study on different animal models of titanium particles inducing osteolysis [J]. Journal of Capital Medical University, 2021, 42(1): 37-42.
[5]	Yuan Huili, Gong Xiaoli, Fan Zheng, Liang Zhigang, Wang Xiaomin. Effects and mechanism of Tenuigenin on lipopolysaccharide induced Parkinson's disease model [J]. Journal of Capital Medical University, 2020, 41(6): 914-922.
[6]	Shi Huanzhong. Focusing on the basic and clinical research of pleural diseases——Professor Shi Huanzhong's group [J]. Journal of Capital Medical University, 2020, 41(5): 736-741.
[7]	Li Yan. A leader in clinical research on dementia in China who guards the “soul of memory”——Professor Jia Jianping [J]. Journal of Capital Medical University, 2020, 41(5): 822-827.
[8]	Liu Xinyao, Ma Chao, Jia Hongxiao. Current status of research concerning animal models of cognitive impairment of schizophrenia [J]. Journal of Capital Medical University, 2020, 41(1): 50-54.
[9]	Ma Denglei, Zhang Xu, Luo Yi, Huang Rui, Li Yali, Li Lin, Zhang Lan. Establishment and characterization of microtubule-associated protein tau over-expression cell and transgenic animal models [J]. Journal of Capital Medical University, 2019, 40(4): 582-587.
[10]	Wang Jia, Le Kai, Guo Yifan, Guo Xu, Zhang Tao, Ren Yu, Wang Ruibin, Xu Guangzhong, Zheng Hailiang, Feng Shuli, Zhu Bin. Early diagnosis of pancreatic cancer in a nude mice model on synchrotron radiation X-ray phase contrast imaging [J]. Journal of Capital Medical University, 2019, 40(2): 195-200.
[11]	Ma Chao, Jia Hongxiao. Current status of research concerning neuroinflammation schizophrenia [J]. Journal of Capital Medical University, 2019, 40(2): 205-208.
[12]	Yang Shuo, Cao Jinxin, Wang Minggang, Lu Jing, Chen Jie, Shen Yingmo, Zou Zhenyu, Liu Yuchen. To establish abdominal wall weakness model in denervated rabbits [J]. Journal of Capital Medical University, 2019, 40(2): 282-285.
[13]	Zou Zhenyu, Yang Shuo, Wang Minggang, Cao Jinxin, Zhong Xingxia, Shen Yingmo, Chen Jie. Experimental study on a novel rabbit model of giant ventral hernia and intra-abdominal hypertension [J]. Journal of Capital Medical University, 2018, 39(6): 900-904.
[14]	Xiao Luyao, Zhang Jie, Zheng Shuai, Mei Shaoshuai. Effects of pH values and doses on intraperitoneal injection of L-arginine induced acute pancreatitis in mice [J]. Journal of Capital Medical University, 2017, 38(5): 700-703.
[15]	Chang Jiahui, Zhao Hui, Wang Lei, Zhang Chi, Lu Yue, Zhang Qiuxia. Effects of chemical components of HSHS on the balance of inflammatory cytokines in LPS-stimulated BV2 cells [J]. Journal of Capital Medical University, 2017, 38(2): 213-219.

Experimental Research on the Effects of a Traditional Chinese Medicine Complex 912 for Injection on Serum Cytokine Levels in the Multiple Organ Dysfunction Syndrome Animal Model

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments