Parathyroid Hormone and Bone Turnover Markers for Diagnosis of Renal Osteodystrophy in Maintenance Hemodialysis Patients

doi:10.3969/j.issn.1006-7795.2010.06.024

Abstract

Abstract: Objective This study was to evaluate the intact parathyroid hormone(iPTH) and parathyroid hormone1-84(PTH1-84) assay with bone turnover markers,such as bone alkaline phosphatase(BALP) and osteocalcin(OC) in maintenance hemodialysis(MHD) patients.Methods Totally 74 hemodialysis patients were enrolled in this study.Clinical data were collected.The control group included 30 healthy people.The serum iPTH,PTH1-84,BALP and OC levels were determined by a specific enzyme linked immunosorbent assay(ELISA).Parathyroid hormone7-84(PTH7-84) level was calculated by iPTH minus PTH1-84.Results The serum iPTH,PTH1-84,BALP levels were significantly higher in MHD patients than in control group(P=0.000).The serum OC levels was higher in MHD patients than in control group(P=0.050).In MHD patients,the serum iPTH and PTH1-84 showed a significant correlation with BALP and OC,respectively(P=0.000).The serum levels of PTH1-84 and conventional iPTH showed a close correlation in dialysis patients(r=0.691,P=0.000).Conclusion Circulating iPTH and PTH1-84 levels are one turnover markers.Combined use of PTH determination with bone turnover markers BALP and OC may be contributive to diagnosis of renal osteodystrophy(ROD).

Key words: hemodialysis, parathyroid hormone, bone turnover

CLC Number:

R691

JIA Yan-li, LIU Hui-lan. Parathyroid Hormone and Bone Turnover Markers for Diagnosis of Renal Osteodystrophy in Maintenance Hemodialysis Patients[J]. Journal of Capital Medical University, 2010, 31(6): 803-807.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2010.06.024

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2010/V31/I6/803

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Parathyroid Hormone and Bone Turnover Markers for Diagnosis of Renal Osteodystrophy in Maintenance Hemodialysis Patients

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