Lectin-like oxidized low-density lipoprotein receptor-1 and the influence from oxidative stress

doi:10.3969/j.issn.1006-7795.2013.04.026

Abstract

Abstract:

Objective To investigate the changes of serum lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and the influence from oxidative stress in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods Totally 94 candidates were divided into three groups according to the apnea-hypopnea index(AHI), including normal control group(n=30), mild to moderate group(n=29), severe group(n=35). After the monitoring by polysomnography(PSG), the blood samples were obtained to measure the levels of serum LOX-1, oxidized low-density lipoprotein(ox-LDL) and malondialdehyde(MDA). Results The levels of serum LOX-1, ox-LDL, MDA in severe OSAHS group were significantly higher than that in the mild to moderate group and control group(P<0.01). The level of serum LOX-1 in OSAHS patients was positively correlated with serum ox-LDL and MDA(r=0.693, 0.460, respectively, all P<0.01). The level of ox-LDL and SaO₂min were the high risk factors to influence the level of serum LOX-1 in patients with OSAHS(r=0.705, 0.734, respectively, all P<0.01). Conclusion The intermittent hypoxia caused by OSAHS can regulate the levels of LOX-1 through oxidative stress, and can further promote the formation and development of atherosclerotic in patients with OSAHS.

Key words: obstructive sleep apnea-hypopnea syndrome, lectin-like oxidized low-density lipoprotein receptor-1, oxidized low-density lipoprotein, malondialdehyde, oxidative stress

CLC Number:

R563

LI Yan, NIE Xiuhong, ZHANG Wei, FAN Xiaojun, REN Kui, GAO Shang. Lectin-like oxidized low-density lipoprotein receptor-1 and the influence from oxidative stress[J]. Journal of Capital Medical University, 2013, 34(4): 609-614.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.04.026

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I4/609

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