Changes of α-synuclein and its oligomeric formation in plasmas of patients with stroke

doi:10.3969/j.issn.1006-7795.2013.06.009

Abstract

Abstract:

Objective To explore the changes of α-synuclein(α-Syn) level in plasma of patients with stroke, and observe the effect of plasma on the formation of oligomeric α-Syn. Methods A total of 50 hospitalized patients with stroke were recruited, they were diagnosed by neurologist of Xuanwu Hospital, Capital Medical University from March to May in 2012. A total of 30 people were recruited as the control group. ELISA was used to evaluate the total α-Syn and the formation of α-Syn oligomers in different groups. Results α-Syn oligomeric formation and total α-Syn level in the plasma of stroke patients was higher than that in controls'. Conclusion Plasma from stroke patients contained high level of total α-Syn and the plasma enhanced formation of oligomeric α-Syn.

Key words: α-synuclein, stroke, plasma

CLC Number:

R742.5

CHEN Yudong, YIN Na, LI Xin, YANG Weiwei, LI Xuran, YU Shun. Changes of α-synuclein and its oligomeric formation in plasmas of patients with stroke[J]. Journal of Capital Medical University, 2013, 34(6): 826-829.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.06.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I6/826

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