Prognostic impact of lymphovascular space invasion in women with early-stage cervical carcinoma

doi:10.3969/j.issn.1006-7795.2015.02.008

Abstract

Abstract: To determine whether lymphovascular space involvement (LVSI) in women with early cervical carcinoma is an independent prognostic factor,and how to deal with it. The literature was reviewed using Medline/Pubmed and known literature to determine if LVSI is an independent risk factor in patients with early-stage cervical carcinoma whether undergoing surgery or taking conservative treatment.A total of 34 articles were identified that satisfied the evaluation criteria; in ten LVSI was confirmed not to be an independent risk factor, and cannot be used as a criterion for reserving fertility in early cervical cancer. In 8 cases LVSI was identified to be related to the prognosis. Clinical observation showed that in LVSI-positive patients, conservative treatment need to be chosen with caution. Using LVSI as the independent determining factor for consideration of post radical hysterectomy radiotherapy appears questionable, and it may be related to lymph metastasis.

Key words: lymphovascular space invasion, cervical cancer, prognosis

CLC Number:

R737

Wang Man, Wang Shuzhen. Prognostic impact of lymphovascular space invasion in women with early-stage cervical carcinoma[J]. Journal of Capital Medical University, 2015, 36(2): 199-204.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.02.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I2/199

References

[1] Morice P, Piovesan P, Rey A, et al. Prognostic value of lymphovascular space invasion determined with hematoxylin-eosin staining in early stage cervical carcinoma:results of a multivariate analysis[J]. Ann Oncol, 2003,14(10):1511-1517.
[2] Milama M R, Frumovitza M, dos Reis R, et al. Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer[J]. Gynecol Oncol, 2007,106(1):12-15.
[3] Yan M, Zhang Y N, He J H, et al. Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma[J]. Chin J Cancer, 2010,29(4):425-430.
[4] Ramirez P T, Pareja R, Rendón G J, et al. Management of low-risk early-stage cervical cancer:should conization, simple trachelectomy, or simple hysterectomy replace radical surgery as the new standard of care?[J]. Gynecol Oncol, 2014,132(1):254-259.
[5] 曹泽毅.中华妇产科学[M].2版.北京:人民卫生出版社,2004.
[6] Delgado G, Bundy B, Zaino R, et al. Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix:a Gynecologic Oncology Group study[J]. Gynecol Oncol, 1990,38(3):352-357.
[7] Sevin B U, Lu Y, Bloch D A, et al. Surgically defined prognostic parameters in patients with early cervical carcinoma. A multivariate survival tree analysis[J]. Cancer, 1996,78(7):1438-1446.
[8] Creasman W T, Kohler M F. Is lymphovascular space involvement a prognostic factor in early stage cervical cancer?[J]. Gynecol Oncol, 2004,92:525-529.
[9] Yu Q, Lou X M, He Y. Prediction of local recurrence in cervical cancer by a Cox model comprised of lymph node status, lymph-vascular space invasion, and intratumoral Th17 cell-infiltration[J]. Med Oncol, 2014,31(1):795.
[10] Yang S H, Kong S K, Lee S H, et al. Human papillomavirus 18 as a poor prognostic factor in stage I-ⅡA cervical cancer following primary surgical treatment[J]. Obstet Gynecol Sci, 2014,57(6):492-500.
[11] Saatli B, Olgan S, Gorken I B, et al. Tumor-free distance from outermost layer of cervix is of prognostic value in surgically treated cervical cancer patients:a multicenter study[J]. Arch Gynecol Obstet, 2014,289(6):1331-1335.
[12] Yamauchi M, Fukuda T, Wada T, et al. Comparison of outcomes between squamous cell carcinoma and adenocarcinoma in patients with surgically treated stage I-Ⅱ cervical cancer[J]. Mol Clin Oncol, 2014,2(4):518-524.
[13] Khunamornpong S, Lekawanvijit S, Settakorn J, et al. Prognostic model in patients with early-stage squamous cell carcinoma of the uterine cervix:a combination of invasive margin pathological characteristics and lymphovascular space invasion[J]. Asian Pac J Cancer Prev, 2013,14(11):6935-6940.
[14] Wang W, Jia H L, Huang J M, et al. Identification of biomarkers for lymph node metastasis in early-stage cervical cancer by tissue-basedproteomics[J]. Br J Cancer, 2014,110(7):1748-1758.
[15] Xiong Y, Cao L P, Rao H L, et al. Clinical significance of peritumoral lymphatic vessel density and lymphatic vessel invasion detected by D2-40 immunostaining in FIGO Ib1-Ⅱa squamous cell cervical cancer[J]. Cell Tissue Res, 2012,348(3):515-522.
[16] Ryu S Y, Kim M H, Nam B H, et al. Intermediate-risk grouping of cervical cancer patients treated with radical hysterectomy:a Korean Gynecologic Oncology Group study[J]. Br J Cancer, 2014,110(2):278-285.
[17] Sopracordevole F, Chiossi G, Barbero M, et al. Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer[J]. Anticancer Res, 2014,34(8):4345-4349.
[18] Plante M, Gregoire J, Renaud M C, et al Simple vaginal trachelectomy in early-stage low-risk cervical cancer:a pilot study of 16 cases and review of the literature[J]. Int J Gynecol Cancer, 2013,23(5):916-922.
[19] Creasman W T, Kohler M F. Is lymph vascular space involvement an independent prognostic factor in early cervical cancer?[J]. Gynecol Oncol, 2004,92(2):525-529.
[20] Kristensen G B, Abeler V M, Risberg B, et al. Tumor size, depth of invasion, and grading of the invasive tumor front are the main prognostic factors in early squamous cell cervical carcinoma[J]. Gynecol Oncol, 1999,74(2):245-251.
[21] Shimada M, Kigawa J, Takahashi M, et al. Stromal invasion of the cervix can be excluded from the criteria for using adjuvant radiotherapy following radical surgery for patients with cervical cancer[J]. Gynecol Oncol, 2004,93(3):628-631.
[22] Magno V, Rivoire W A, Mõnego H, et al. Prevalence and Relapse Impact of Lymphovascular Invasion at Early-Stage Cervical Cancer:Prevalence of Lymphovascular Invasion in Cervical Cancer[J]. J Low Genit Tract Dis, 2009,13:256-259.
[23] Alexander-Sefre F, Singh N, Ayhan A, et al. Detection of tumourlymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry[J]. J Clin Pathol, 2003,56(10):786-788.
[24] Peters W A 3rd, Liu P Y, Barrett R J 2nd, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix[J]. J Clin Oncol, 2000,18(8):1606-1613.
[25] Lim C S, Alexander-Sefre F, Allam M, et al. Clinical value of immunohistochemically detected lymphovascular space invasion in early stage cervical carcinoma[J]. Ann Surg Oncol, 2008,15(9):2581-2588.
[26] Ssykes P, Allen D, Cohen C, et al. Does the density of lymphatic vascular space invasion affect the prognosis of stage Ib and ⅡA node negative carcinoma of the cervix?[J]. Int J Gynecol Cancer, 2003,13(3):313-316.
[27] Scurry J, Hacker N F, Barlow E, et al. Is quantification of lymphovascular space invasion useful in stage 1B2 cervical carcinomas?[J]. J Obstet Gynaecol, 2014,27:1-5.
[28] Uzan C, Gouy S, Desroque D, et al. Analysis of a continuous series of 34 young patients with early-stage cervical cancer selected for a vaginal radical trachelectomy:should staging conization be systematically performed before this procedure?[J]. Int J Gynecol Cancer, 2013,23(2):331-336.
[29] Wang Y, Wang G, Wei L H, et al. Neoadjuvant chemotherapy for locally advanced cervical cancer reduces surgical risks and lymph-vascular space involvement[J]. Chin J Cancer, 2011,30(9):645-654.
[30] Qian Q, Yang J, Cao D, et al. Analysis of treatment modalities and prognosis on microinvasive cervical cancer:a 10-year cohort study in China[J]. J Gynecol Oncol, 2014,25(4):293-300.
[31] Sopracordevole F, Chiossi G, Barbero M, et al. Surgical approach and long-term clinical outcome in women with microinvasive cervical cancer[J]. Antic Res, 2014,34(8):4345-4349.
[32] 林仲秋,李孟达,吴少雄,等.宫颈癌及癌前病变的处理[J].现代妇产科进展,2006,15(8):563-572.
[33] 谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013.
[34] 李晓霞,盛修贵.早期宫颈癌广泛性宫颈切除术研究进展[J].中华肿瘤防治杂志,2012,19(8):638-640.