Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (4): 435-437.

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Effective of Quercetin on the Expression of Caspase-3 in AMI Rat

Ji Fengqing1, Li Baohong1, Sun Haimei1, Zeng Xiaobei1, Tang Yu2   

  1. 1. Department of Histology and Embryology, Capital University of Medical Sciences;2. Department of Pharmacology, Capital University of Medical Sciences
  • Received:2004-09-03 Revised:1900-01-01 Online:2004-10-15 Published:2004-10-15

Abstract:

The aim was to study the effect of quercetin on the expression of caspase-3 in acute myocardial ischemia (AMI). In the rat model of acute myocardial ischemia, the expression of caspase-3 was investigated with immunohistochemical method. The expression of positive cells were measured by image analysis. The expressions of caspase-3 in the AMI group are higher than the sham group, and quercetin could inhibit the expression of caspase-3 in AMI rat. It suggest that quercetin could significantly inhibit the expressions of caspase-3 in AMI. It may be the one of protective mechanisms on impaired myocardium.

Key words: quercetin, AMI, caspase-3

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