Abstract: The aim was to study the expression of HSP70 and grp94 in human esophagus carcinoma(EC). HSP70 and grp94 expression were detected immunohisto-chemically, the character of which were analyzed with biological microscope. Of 54 cases of HCC, 92.6%(50/54) showed HSP70 positive stain, and the expression character were various and different, while grp94 was mainly stained in cell plasma, and the positive rate was 70.4%(38/54). Condusions: owing to the heteroity in EC, HSP70 and grp94 expressed differently in cell plasma and nucleolus. The expression rule of HSP70 and grp94 in EC will lay a better foundation on tumor vaccine.

Key words: esophagus carcinoma, heat shock protein-70, glucosal-related protein-94, immunohistochemistry