Study on the Expression of Ki-67 and Apoptosis in the Pancreas Cancer Cell Line Bxpc-3

Abstract

Abstract: To test the realtionship between Ki-67 index and apoptosis in the pancreas cancer cell line Bxpc-3, apoptosis was inducted by 1,25(OH)₂D₃ in the pancreas cancer cell line. We compared the cell number by MTT, determined quantitatively apoptosis cells by TUNEL, detected the expression of Ki-67 index by immunohistochemical. Results suggested that the expression of the Ki-67 index was decreased during apoptosis induced by 10^-8mol/L 1,25(OH)₂D₃ in Bxpc-3 cell line. There was negative correlation between the apoptosis and the expression of Ki-67 index. Comprehensive analysis of the apoptosis and Ki-67 index reflects the balance of proliferation and apoptosis.

Key words: 25-(OH)₂D₃, Bxpc-3, apoptosis, Ki-67

CLC Number:

Liu Shuang;Liu Dachuan;Li Fei;Sun Jiabang. Study on the Expression of Ki-67 and Apoptosis in the Pancreas Cancer Cell Line Bxpc-3[J]. Journal of Capital Medical University, 2003, 24(3): 307-309.

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Study on the Expression of Ki-67 and Apoptosis in the Pancreas Cancer Cell Line Bxpc-3

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