Expression of Lung-resistance Protein, Epidermal Growth Factor Receptor and HER-2 in Breast Infiltrating Duct Cancer and Its Clinical Significance

doi:10.3785/j.issn.1006-7795.2009.03.005

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (3): 282-284.doi: 10.3785/j.issn.1006-7795.2009.03.005

• 肿瘤学 • Previous Articles Next Articles

Expression of Lung-resistance Protein, Epidermal Growth Factor Receptor and HER-2 in Breast Infiltrating Duct Cancer and Its Clinical Significance

LIN Fang-cai¹, LI Qiu-yang², SUN Xin¹, Wu Fang², CHEN Hui-li², SU Chun-xiang²

1. Department of General Surgery, Beijing Dianli Hospital; Department of Oncology, Capital Medical University;2. Department of Pathology, Beijing Dianli Hospital

Received:2009-03-18 Revised:1900-01-01 Online:2009-06-21 Published:2009-06-21

Abstract

Abstract: Objective To investigate expression of lung-resistance protein(LRP), epidermal growth factor receptor(EGRR) and HER-2 in breast infiltrating duct carcinoma, and evaluate its clinical significance. Methods Expression of LRP, EGFR, HER-2, and vascular endothelial growth factor(VEGF) in breast cancer tissues from 76 patients were detected by using immunohistochemical techique. Results 1) The positive rate of LRP, EGFR, HER-2, and VEGF were 35.53%, 15.79% and 25%, respectively. There was no significant correlation among these factors in expression. 2) The expression of LRP was negatively correlated with the grade of tumor. 3) The expression of LRP, EGFR, HER-2 and VEGF was not correlated with lymph node metastasis. Conclusion Expression of LRP may play an important role in the malignant progression of the breast cancer, and could be used to judge the grade of breast cancer.

Key words: breast cancer, immunohistochemistry, lung-resistance protein, epidermal growth factor receptor, HER-2

CLC Number:

R 737.9

LIN Fang-cai;LI Qiu-yang;SUN Xin;Wu Fang;CHEN Hui-li;SU Chun-xiang. Expression of Lung-resistance Protein, Epidermal Growth Factor Receptor and HER-2 in Breast Infiltrating Duct Cancer and Its Clinical Significance[J]. Journal of Capital Medical University, 2009, 30(3): 282-284.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3785/j.issn.1006-7795.2009.03.005

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2009/V30/I3/282

[1]	Zhao Yue, Ruan Xiangyan, Cheng Jiaojiao, Gu Muqing, Xu Xin, Wang Yuejiao. Breast cancer pathological diagnosis reveals correlation between progesterone receptor membrane component 1 and clinicopathological parameters [J]. Journal of Capital Medical University, 2022, 43(3): 350-356.
[2]	Yao Shuyang, Li Xiaoxue, Wang Chunxiu, Zhang Yi. Icotinib plus antiangiogenic agent as the first-line treatment for advanced EGFR mutant lung adenocarcinoma: a single-center study [J]. Journal of Capital Medical University, 2022, 43(2): 289-293.
[3]	Wei Changsheng, Luo Chengyu, Zhang Shuqi. Application of periareolar incision combined with mastoscopic axillary lymph node dissection in breast conserving surgery for early breast cancer [J]. Journal of Capital Medical University, 2021, 42(6): 1014-1020.
[4]	Ruan Xiangyan, Yang Yu, Lu Dan, Du Juan, Cheng Jiaojiao, Gu Muqing, Li Yanglu, Jin Fengyu, Duan Wei, Dai Yinmei, Ju Rui, Xu Xin, Matthias Korell, Alfred O. Mueck. The first successful case report of breast cancer patient's cryopreserved ovarian tissue transplantation in China and literature review [J]. Journal of Capital Medical University, 2021, 42(2): 177-182.
[5]	Yang Yang, Kang Hua, Zhao Jing, Ling Yuwei, Zhao Ye, Wang Yajun, Rong Dongdong. Retrospective analysis of preoperative breast MRI of breast cancer patients with breast conserving surgery [J]. Journal of Capital Medical University, 2020, 41(6): 943-953.
[6]	Wu Xikang, Wang Yue, He Huiying. Expression and significance of Slit guidance ligand 3 in upper tract urothelial carcinoma [J]. Journal of Capital Medical University, 2020, 41(3): 354-359.
[7]	Wang Aiting, Yan Dan, Qi Xianrong. Evaluation of the inhibitory effect of docetaxel-loaded polymeric micelles on breast cancer metastasis in mice [J]. Journal of Capital Medical University, 2020, 41(2): 225-230.
[8]	Wang Wei, Zhang Zihan, Zhai Yan, Sang Cuiqin, Wang Shuzhen. Clinical characteristics of the double primary malignant tumors of uterine corpus/breast [J]. Journal of Capital Medical University, 2019, 40(6): 857-862.
[9]	Zhang Yunxian, Wang Yamei, Zhou Ping. Construction and functional analysis of circular RNA interaction network based on open chromatin in breast cancer [J]. Journal of Capital Medical University, 2019, 40(6): 901-910.
[10]	Bai Xiangdong, Hao Yating, Zhang Xinxue, He Qiang. Clinical efficacy of lineal polypeptide injection combined with chemotherapy in triple-negative breast cancer patients [J]. Journal of Capital Medical University, 2019, 40(6): 911-915.
[11]	Zhang Lingyan, Ruan Xiangyan, Cai Guiju, Gu Muqing, Alfred O. Mueck. Effect of tamoxifen on Ki-67 expression in breast tumor tissue of nude mice transfected with progesterone receptor membrane component 1 [J]. Journal of Capital Medical University, 2019, 40(4): 533-538.
[12]	Wang Yuejiao, Ruan Xiangyan, Gu Muqing, Cai Guiju, Li Xue, Zhang Lingyan, Alfred O. Mueck. Tamoxifen treated breast cancer xenograft in nude mice and uterine pathological changes [J]. Journal of Capital Medical University, 2019, 40(4): 539-543.
[13]	Bai Xiangdong, Hao Yating, Zhang Xinxue, He Qiang. Effects of combined lienal polypeptide injection and postoperative chemotherapy on estrogen receptor-positive and estrogen receptor-negative patients [J]. Journal of Capital Medical University, 2019, 40(3): 443-448.
[14]	Chen Nina, Fan Yichang, Shang Kun, Yang Jing, Cao Bangwei. Serum lipid and apolipoprotein levels were associated to the Ki-67 and molecular classification of breast cancer [J]. Journal of Capital Medical University, 2019, 40(2): 191-194.
[15]	Li Xue, Ruan Xiangyan, Gu Muqing, Cai Guiju, Zhao Yue, Alfred O. Meuck. Progesterone receptor membrane component 1 increases hormone induced proliferation of breast cancer cells——E2 vs sequential combination vs continuous combination [J]. Journal of Capital Medical University, 2019, 40(2): 237-243.

Expression of Lung-resistance Protein, Epidermal Growth Factor Receptor and HER-2 in Breast Infiltrating Duct Cancer and Its Clinical Significance

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments