Journal of Capital Medical University ›› 2015, Vol. 36 ›› Issue (2): 251-254.doi: 10.3969/j.issn.1006-7795.2015.02.016

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NHERF3 expression level and its significance in renal cell carcinoma

Fa Pengyan1, Liu Hua1, Zheng Junfang1, Wang Lei2, Dai Yuanping1, He Junqi1   

  1. 1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China;
    2. Department of Urology Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Received:2015-02-08 Published:2015-04-16
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81372739), Basic-Clinical Scientific Research Cooperation Fund of Capital Medical University(13JL73).

Abstract: Objective To analysis the difference of the expression level of NHERF3 between renal cell carcinoma and its adjacent tissues. Methods To detect the expression of NHERF3 protein by immunohistochemistry and Western blotting, mRNA by RT-PCR in renal cell carcinoma and their corresponding adjacent tissues. Results NHERF3 protein and mRNA level is significantly decreased in renal cell carcinoma when compared with that in adjacent tissues. Conclusion NHERF3 gene expression was significantly inhibited at the transcriptional level.

Key words: renal cell carcinoma, NHERF3, gene expression

CLC Number: