Abstract: Objective To investigate the clinical features, treatment regimen and prognosis of patients with thrombotic thrombocytopenic purpura (TTP), and to improve the level of TTP diagnosis and treatment. Methods The clinical manifestation, laboratory examination, treatment and prognosis of 30 patients with TTP hospitalized in our hospital from April 2012 to December 2018 were analyzed retrospectively.Results Among the 30 TTP patients, there were 14 males and 16 females, with an average age of (51.33±14.88)years, 17 with triad (57%), 11 with pentad (37%);2 with exacerbation, 2 with recurrence, 1 with refractory, and 16 with death (53%). Twenty-four patients were performed plasma exchange, and there was statistically significant difference in mortality between the plasma exchange group and the non-plasma exchange group (P<0.05).There was no statistically significant difference in mortality between the number of plasma exchange less than or equal to 4 times and the number of plasma exchange>4 times (P>0.05). There were statistically significant differences in hemoglobin, platelet and lactate dehydrogenase values before and after plasma exchange (P<0.05).Conclusion TTP diagnosis needs to be based on clinical manifestations and laboratory examination. Plasma exchange can significantly reduce the mortality of TTP patients, and should be applied as soon as possible after diagnosis.

Key words: thrombotic thrombocytopenic purpura, clinical features, prognosis