Effects and mechanism of Tenuigenin on lipopolysaccharide induced Parkinson's disease model

doi:10.3969/j.issn.1006-7795.2020.06.009

Abstract

Abstract: Objective To investigate the effects of Tenuigenin (TEN) on lipopolysaccharide (LPS) -induced rat model of Parkinson's disease (PD). Methods Five experimental groups were set up to analyze the effect and mechanism of TEN on PD rats, with animal behavior tests, detection of inflammatory cytokines in the substantia nigra and plasma, detection of the survival rate of dopamine (DA) neurons and observation of morphological sections of major metabolic organs. Results The treatment with TEN improved motor impairment induced by LPS. Also, TEN significantly ameliorated the degeneration of dopaminergic neurons and inhibited the secretion of proinflammatory cytokines in substantia nigra. Furthermore, TEN had no effect on the major metabolic organs. Conclusion TEN showed neuroprotective effect on PD rats. The mechanism is related to the anti-inflammatory activity of TEN.

Key words: Tenuigenin, Parkinson's disease, lipopolysaccharide, cytokines, inflammatory response

CLC Number:

R741.02

Yuan Huili, Gong Xiaoli, Fan Zheng, Liang Zhigang, Wang Xiaomin. Effects and mechanism of Tenuigenin on lipopolysaccharide induced Parkinson's disease model[J]. Journal of Capital Medical University, 2020, 41(6): 914-922.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.06.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I6/914

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