The Differentiation of Th1 and Th2 CD4+ T Lymphocytes of Peripheral Blood from Lung Cancer Patients

Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 17-19.

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The Differentiation of Th1 and Th2 CD4⁺ T Lymphocytes of Peripheral Blood from Lung Cancer Patients

Bai Peng¹, Zhang Husheng¹, Wang Yuzhou²

1. Department of Respiratory Diseases, Beijing Tongren Hospital, Capital University of Medical Sciences;2. Department of Oncology, Peking Union Medical College Hospital

Received:2005-12-16 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

Abstract

Abstract: Objective To evaluate the differentiation of Th1 and Th2 CD4⁺ T lymphocytes of peripheral blood from lung cancer patients.Methods Interferon-γ(IFN-γ) and interleukin-4(IL-4) levels in CD4⁺ T lymphocytes of peripheral blood from 25 lung cancer patients and 25 healthy volunteers were detected using flow cytometry.IFN-γand IL-4 were used as markers for the differentiation of Th1 and Th2 subsets,respectively.Results IFN-γwas lower in CD4⁺ T lymphocytes from lung cancer patients than that from healthy controls.No difference was found for IL⁴.Conclusion The ratio of Th1 to Th2 subsets changed in lung cancer patients,which may be one of the mechanisms for the tumor to escape from the immune surveillance.

Key words: lung cancer, Th1/Th2 cells, IL-4, IFN-γ

CLC Number:

R734.2

Bai Peng;Zhang Husheng;Wang Yuzhou. The Differentiation of Th1 and Th2 CD4⁺ T Lymphocytes of Peripheral Blood from Lung Cancer Patients[J]. Journal of Capital Medical University, 2006, 27(1): 17-19.

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The Differentiation of Th1 and Th2 CD4⁺ T Lymphocytes of Peripheral Blood from Lung Cancer Patients

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