Clinical Study of Controlled-Release formula of Glipizide in the Treatment of Coronary Artery Disease Complicated with Type 2 Diabetes Mellitus

Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 78-80.

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Clinical Study of Controlled-Release formula of Glipizide in the Treatment of Coronary Artery Disease Complicated with Type 2 Diabetes Mellitus

Zhao Xiuli¹, Zhou Yanming², Yang Jinkui³, Li Jincheng4⁴, Zhang Hui¹, Wu Ying¹, Zhang Renhan¹, Hu Dayi¹

1. Heart Center, Beijing Tongren Hospital, Capital University of Medical Sciences;2. Ankang Hospital of Heilongjiang Province;3. Department of Endocrinology, Beijing Tongren Hospital;4. Department of Clinical Lab, Beijing Tongren Hospital

Received:2005-01-10 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

Abstract

Abstract: Objective To compare the safety and efficacy of controlled-release formula of glipizide and immediate release glipizide in the treatment of coronary artery disease complicated with type 2 diabetes mellitus.Methods 60 patients were randomized into two groups,each group has 30 patients,receiving controlled-release formulation of glipizide or immediate release glipizede respectively.The level of glucose,insulin,C-peptide and HbA1c were measured before and after treatment.Results controlled-release formula of glipizide once daily and immediate release glipizide 3 times per day showed a similar effect on glucose level,but the former did not increase insulin and C-peptide level.Conclusion The controlled-release formula of glipizide had safe and reliable effects on controlling glucose and had no adverse effect to insulin and C-peptide in treatment of coronary artery disease complicated with type II diabetes mellitus.

Key words: controlled-release formula of glipizide, coronary artery diseases, diabetes mellitus

CLC Number:

Zhao Xiuli;Zhou Yanming;Yang Jinkui;Li Jincheng;Zhang Hui;Wu Ying;Zhang Renhan;Hu Dayi. Clinical Study of Controlled-Release formula of Glipizide in the Treatment of Coronary Artery Disease Complicated with Type 2 Diabetes Mellitus[J]. Journal of Capital Medical University, 2006, 27(1): 78-80.

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Clinical Study of Controlled-Release formula of Glipizide in the Treatment of Coronary Artery Disease Complicated with Type 2 Diabetes Mellitus

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