Changes of Cytokines in the Multiple Organ Dysfunction Syndrome in Animals

Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 92-94.

• 临床研究 • Previous Articles Next Articles

Changes of Cytokines in the Multiple Organ Dysfunction Syndrome in Animals

Ren Tianhua¹, Zhang Shuwen², Ren Aiming², Jiang Yue³, Wang Baoneng²

1. Department of Gastroenterology, Beijing Tiantan Hospital, Capital University of Medical Sciences;2. Department of Cardiovascular, Beijing Tiantan Hospital, Capital University of Medical Sciences;3. Department of Infection and Critical Care, Beijing Friend Hospital, Capital University of Medical Sciences

Received:2005-03-28 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

Abstract

Abstract: Objective The aim of this study was to investigate the changes of cytokines in the multiple organ dysfunction syndrome(MODS) animals.Methods 16 one-year-old male swines,weight 20～25 kg,were used for this study.Bacillius(17 million/kg) were injected into right jugular,and serum endotoxin and cytokins(TNF,IL-1,IL-6,IL-10,NO) were determined 1 h,3 h,5 h,7 h after injections.Results Serum cytokines were increased 1 h after injections with standard colon bacillius.Standard colon bacilius-induced changes in cytokine levels were time-dependent.Conclusion These findings provide some experimental basis for the clinical study of MODS.

Key words: multiple organ dysfunction syndrome, animal model, cytokines

CLC Number:

Q95.33

Ren Tianhua;Zhang Shuwen;Ren Aiming;Jiang Yue;Wang Baoneng. Changes of Cytokines in the Multiple Organ Dysfunction Syndrome in Animals[J]. Journal of Capital Medical University, 2006, 27(1): 92-94.

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Changes of Cytokines in the Multiple Organ Dysfunction Syndrome in Animals

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