Follow-up study on rehabilitation therapy of oxidative stress in patients with stable chronic obstructive pulmonary disease

doi:10.3969/j.issn.1006-7795.2013.04.027

Abstract

Abstract:

Objective To investigate the effects of pulmonary rehabilitation on oxidative stress in patients with stable chronic obstructive pulmonary disease(COPD). Methods Fifteen(10 males, 5 females) stable COPD patients, mean(SD) age 55.73(9.75) years, body mass index(BMI) 21 kg/m² to 32 kg/m²〔an average of (25.60±2.99)kg/m²〕, forced expiatory volume in one second(FEV1)/predicted more than 30%, were enrolled into this 48 weeks of rehabilitation program. The response of cytokine were measured at pre-, post- and first post-maximal exercise training. The response of oxidative stress was measured from serum level of malondialdehyde(MDA) and superoxide dismutase(SOD). A p-value of less than 0.05 was considered significant for the results of all stratified analyses. Results Fifteen patients completed the study. There was no significant change in level of MDA and SOD between pre- and first post-maximal exercise training(P>0.05). The cytokine level of serum MDA was markedly decreased after 48 weeks exercise training, compared to that before training(P<0.05). The level of serum SOD was significantly increased after 48 weeks training, compared to that before training(P<0.05). Conclusion The level of oxidative stress was significantly improved by 48 weeks exercise training. There was no significant response of oxidative stress associated with maximal exercise before or after training in COPD patients.

Key words: chronic obstructive pulmonary disease(COPD), pulmonary rehabilitation(PR), oxidative stress

CLC Number:

R563.3

ZHOU Wenbo, NIE Xiuhong. Follow-up study on rehabilitation therapy of oxidative stress in patients with stable chronic obstructive pulmonary disease[J]. Journal of Capital Medical University, 2013, 34(4): 615-618.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.04.027

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I4/615

References

[1] Celli B R, MacNee W. ATS/ERS, Task force1 standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper[J]. Eur Respir J, 2004,23:9322-9461.

[2] 朱裴钦,罗勇,徐卫国.慢性阻塞性肺疾病预后因素和死亡预测因子[J].国际呼吸杂志,2007,27(1):270-273.

[3] Deeramer M. Pulmonary rehabilitation 2007: from bench to practice and back[J]. Clin Invest Med, 2008,3(1):E312-E318.

[4] Gosker H R, Zeegers M P, Wouters E F, et al. Muscle fibre type shifting in the vastus Iateralis of patients with COPD is associated with disease severity: a systematic review and meta analysis[J]. Throax, 2007,6(2):944-949.

[5] Foschino Barbaro M P, Carpagnano G E, Spanevello A, et al. Inflammation, oxidative stress and systemic effects in mild chronic obstructive pulmonary disease[J]. Int J Immunopathol Pharmacol, 2007,20(1):753-763.

[6] 李建华.慢性阻塞性肺疾病稳定期的药物治疗进展[J].中国煤炭工业医学杂志,2012,15(3):465-468.

[7] 罗勇.COPD早期药物干预和非常地药物治疗进展及热点扫描[J].临床误诊误治,2012,25(8):8-12.

[8] Charvoshan B, Fournier M, Lewis M I, et al. Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men[J]. Respiratory Med, 2012,106(2):55-62.

[9] Ambrosion N, Casaburi R, Ford G, et al. Developing concepts in the pulmonary rehabilitation of COPD[J]. Respiratory medicine, 2008,102(1):144-161.

[10] Wust R C, Degens H. Factors contributing to muscle wasting and dysfunction in COPD patients[J]. Int J Chron Obstrudt Dis, 2007,5(2):289-300.

[11] Kenn K, Heinzelmann N. Pulmonary rehabilitation(Rehabilitation in der Pneumologie)[J]. DMW, 2012,137(31):623-633.

[12] Dodd J W, Hogg L, Nolan J, et al. The COPD assessment test(CAT): response to pulmonary rehabilitation. A multicentre, prospective study[J]. Thorax, 2011,66(5):77-84.

[13] Costi S, Crisafulli E, Anyoni F D. Effects of unsupported upper extremity exercise training in patients with COPD: a randomized clinical trial[J]. Chest, 2009,136(2):521-529.

[14] Fernoselle C, Rabinovich R, et al. Does oxidative stress modulate limb muscle atrophy in severe COPD patients?[J].The Eur J Respir Dis, 2012, 40(4):211-221.

[15] Dyer F, Callaghan; Cheema k, et al. Ambulatory oxygen improves the effectiveness of pulmonary rehabilitation in selected patients with chronic obstructive pulmonary disease[J]. Chronic Respiratory Disease, 2012,9(2):661-672.