Relationship between Plasma Estrogen and Lipid Peroxides in Women

Abstract

Abstract: Plasma estradiol(E₂)and malondialdehyde(MDA)were examined in women,and the results demonstrated that E₂ level decreased and MDA content increased in menopausal wo-men,showing a negative correlalivity between E₂ and MDA.In animal experiment we found that E₂ was decreased while MDA in liver and uterine homogenates was increased,adminis-tration of estrogen reversed the change of MDA in liver and uterus,and the range of change of MDA in uterus with E₂ was more significant than that in liver.The results suggest that E₂ may possess the antioxidative effect.Therefore,the manifestations of senescence are probably related with the increase of MDA resulting from the decrease of E₂ level.

Key words: estrogen, malondialdehyde(MDA), lipid peroxidation

CLC Number:

R711.51

Cao Junqing;Yang Guilin;Sun Suhua;Wu Qianhu. Relationship between Plasma Estrogen and Lipid Peroxides in Women[J]. Journal of Capital Medical University, 1993, 14(1): 49-51.

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Relationship between Plasma Estrogen and Lipid Peroxides in Women

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