Abstract: In order to assese the relationship between HP infection and gastric carcinoma, we detected the presence of HP with culture and examinated the level of HP serum antibodies(ELISA)in 73 gastric cancer patients and 73 controls matched for age and sex.Patients and controls were selected on referral for gastroscopy.It was showed that the prevalence of HP infection in gastric cancer patients was 58.9% and 53.42% in controls.the high levels of serum antibodies were found in 67.12% of cases and 57.53% of controls.These differences are not statistically significant.Tumor histology and site had no effect on the presence of HP.We conclude that gastric cancer is a multifactorial disease.HP infection is neither only nor necessary for gastric carcino-genesis.Somefactors may cause gastric malignancy with or based on some special HP strain infections.

Key words: Helicobacter pylori(HP), gastric cancer, anti-HP antibodies