Abstract: To study clinical and endoscopic feature and possible pathogenesis of hepatogenous peptic ulcer(HPU), The endoscopic and clinical materials were analysed and microelements of 164 patients with chronicliver diseases and 36 patients with acute hepatitis were detected by WFX 1Datomic absorption spectrophotometry.The incidence of HPU was 40 %.Of them, Duodenal ulcer accounted for 88.8 %.Average age was 46.8 year old.Atypicalsy mptomtic HPU was observed.Seru m Zn was decreased(P < 0.05) and Fe wasslightly increased(P < 0.05).The positive relationship between theincidence of HPU and the degree ofliver diseases was observed.The resultshowed that HPUdiffered from com mon peptic ulcer,and the pathogenesisis unclear.It was may be results from increased attactfactors and decreased protect factors in patients with chronicliver diseases.

Key words: hepatogenous peptic ulcer, microelement, chronic hepatitis, cirrhosis