Journal of Capital Medical University ›› 2000, Vol. 21 ›› Issue (1): 43-45.

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The Serum Levels of Soluble Fas in Patients with Malignant Hematologic Diseases and its Clinical Implication

Zheng Jia, Liu Fuqiang, Zhai Yanling, Liu Yuanpo, Wang Tian, Li Shoujing, Zhao Xiangyin   

  1. Department of Hematology, Beijing Tongren Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1999-02-06 Revised:1900-01-01 Online:2000-01-15 Published:2000-01-15

Abstract: In order to study the serum levels of soluble Fas (sFas) in malignant hematologic diseases and its clinical implication, serum levels of sFas in 60 patients with malignant hematologic diseases and in a control group of 30 health volunteers were measured by sandwich enzyme linked immunosorbent assay (ELISA) method.Before chemotherapy, the serum levels of sFas in patients with malignant hematologic diseases were significantly higher than those of control group(P<0.01), and were not related to respose to chemotherapy. After chemotherapy, the levels of sFas significantly lowered in complete remission (CR) group (P<0.05), but did not in unremission (NR) group. The levels and changes of sFas might be served as a reference finger to diagnosis some malignant hematologic diseases and to evaluate chemotherapy effect. sFas might be involved in pathogenesis of some malignant hematologic diseases .

Key words: soluble Fas, malignant hematologic diseases, apoptosis

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