Abstract: To evaluate the influence of uremia and hemodialysis on nitrogen oxide(NO) product and it′s clincal value, serum levels of nitrogen oxide were measured in 10 uremia undialyzed patients, 14 hemodialysis patients and 10 normal controls. Nitrogen oxide levels were significantly higher in undialyzed patients and hemodialysis patients than normal controls(P<0.05). NO level was correlated with tumor necrosis factor α in ureamia undialyzed patients(r=0.858, P<0.001). Nitrogen oxide decreased considerably (P<0.05) after hemodialysis but store up again during the interim. The result suggested that enhanced nitrogen oxide product might contribute to some uremic syndromes.

Key words: uremia, hemodialysis, nitrogen oxide, tumor necrosis factor-α