Influence of Hemodialyzer Membranes on Apoptosis of Peripheral Blood Mononuclear Cell

Journal of Capital Medical University ›› 2001, Vol. 22 ›› Issue (3): 232-235.

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Influence of Hemodialyzer Membranes on Apoptosis of Peripheral Blood Mononuclear Cell

Liu Huilan¹, Wang Ying¹, Zhang Xiaojie¹, Zhao Yanchi¹, Zhang Haiyan², Li Weihong²

1. Department of Nephrology, Beijing Fuxing Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Cell Biology, Capital University of Medical Sciences

Received:2000-06-09 Revised:1900-01-01 Online:2001-07-15 Published:2001-07-15

Abstract

Abstract: This study investigated the influence of hemodialyzer membranes on apoptosis of peripheral blood mononuclear cell. PBMC were seperated from whole blood donated by healthy volunteers . They were incubated in vitro in the presence of either CU membrane or Gambrane membrane . Control cells were incubated in absence of HD membranes. The cells were collected at regular intervals. PBMC apoptosis were evaluated with flowing cetometric analysis. The results indicated that the apoptosis of PBMC in each group increased more obviously than that before the incubation 48 h ago. Apoptosis of CU group was(36.31±1.40)%, significantly higher than other two groups(P<0.05). CU membrane, a bioincompatible HD membrane, can induce the isolated PBMC to apoptosis more easily than others.

Key words: hemodialysis membrane, apoptosis, biocompatibility

CLC Number:

R459.5

Liu Huilan;Wang Ying;Zhang Xiaojie;Zhao Yanchi;Zhang Haiyan;Li Weihong. Influence of Hemodialyzer Membranes on Apoptosis of Peripheral Blood Mononuclear Cell[J]. Journal of Capital Medical University, 2001, 22(3): 232-235.

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Influence of Hemodialyzer Membranes on Apoptosis of Peripheral Blood Mononuclear Cell

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