Abstract: To determine the clinical efficacy of amiodarone in fast atrial fibrillation in patients with acute myocardial infarction, 48 acute myocardial infarction patients with recent onset of fast atrial fibrillation were observed. After an intravenous load, intravenous amiodarone was administered continuously. Efficacy of amiodarone in the reversion of atrial fibrillation and the control of ventricular rate as well as the side effects were observed. The ventricular rates of 15 min, 30 min, 1 h, 6 h, 24 h after the administration of amiodarone in the 48 patients were(107.17±9.67)beats/min,(96.00± 8.39)beats/min,(88.13±9.98)beats/min,(79.88±10.19)beats/min,(74.88±9.80)beats/min respectively, which were lower than the rate(130.58±9.15)beats/min before the drug was given. Atrial fibrillation was reverted to sinus rhythm within 24 h in 48 cases. Sinus bradycardia was observecd in 3 patients. Sinus bradycardia and Ⅱ°Ⅱ type AVB occurred in 1 patient. Intravenous amiodarone is effective and safe in the treatment of fast atrial fibrillation in patients with AMI.

Key words: amiodarone, acute myocardial infarction, atrial fibrillation