Abstract: The objective was to analyse the clinical characteristic, risk factors and prognosis of severe acute pancreatitis (SAP) with fungal infection. Retrospective analysis of 85 cases of SAP with infection was carried out. Among them 43 cases were with fungal infection, and others with bacterial infection. There were no significant differences in age, sex, etiology between the two groups. In the fungal group, APACHE Ⅱ score, CT score, times of operation were higher than the bacterial group. Flora disorder, increased abdominal express and MODS were more often found in fungal infection cases. Mortality in fungal group was twice more than that in the bacterial group(44.19% : 21.43% ). Conclusion: Fungal infection can increase mortality of SAP. APACHE Ⅱscore, CT score, Flora disorder, increased abdominal express and times of operation are risk factors of fungal infection. Unknown fever, consciousness change and heavy bleeding may indicate fungal infection. Antifungal Prophylaxis will benefit the treatment of SAP.

Key words: pancreatitis, fungal infection, complication