Effects of Manganese withdifferent Valence on Lipid Peroxidation in 18-Month-Old Rats

Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (1): 1-3.

• 论著·基础研究 • Previous Articles Next Articles

Effects of Manganese withdifferent Valence on Lipid Peroxidation in 18-Month-Old Rats

Chu Jinhua¹, Geng Rong², Zhang Shuhua¹, Liu Di³, Xuan Dengfeng¹, Zhao Feng¹, Zhang Jie¹, Li Guojun¹

1. Public Health and Family Medical School, Capital University of Medical Sciences;2. Fengtai Center for Disease Control and Prevention;3. China Disabled Persons'Federation Social Service Guidance Genter

Received:2003-06-14 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

Abstract

Abstract: The aim was to u nderstand the effects of manganese with different valence on the status lipid pe roxidation and antioxidation in rats. Methods: mice were treated with MnCl₂ or C₆H₉O₆ Mn·2H₂O or sterile saline by intraoeritioneal injection for one month, then the concentration of MDA and the activity of SOD in brain, liver and heart were determined. In the rat's brain treated with the two different manganese, the concentration of MDA increased with the decrease of SOD, contras ted with those treated with sterile saline. In liver, to those samp les treated with MnCl₂, the concentration of MDA and the activity of the SOD i ncreased and decreased respectively, contrasted with the other two groups. In he art, however, no difference was fond in three groups. The results show that the toxicity of manganese with different valence on the old rat's different organizes are vari ous.

Key words: manganese, lipid peroxidation, SOD, MDA

CLC Number:

R135.1

Chu Jinhua;Geng Rong;Zhang Shuhua;Liu Di;Xuan Dengfeng;Zhao Feng;Zhang Jie;Li Guojun. Effects of Manganese withdifferent Valence on Lipid Peroxidation in 18-Month-Old Rats[J]. Journal of Capital Medical University, 2004, 25(1): 1-3.

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Effects of Manganese withdifferent Valence on Lipid Peroxidation in 18-Month-Old Rats

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