Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (1): 4-6.

• 论著·基础研究 • Previous Articles     Next Articles

Regulation of Oxygen Freeradical in RatCerebrum with Chinese Herbs, Suifukang

Huang Changsheng1, Sun Congxiao1, Han Fengyue1, Yang Lin2, Chen Yaliang2, Liu Na2   

  1. 1. Lab. of Neurobiology, Inst. of Orthopaedics and Traumatology, China Aca demy of TCM;2. Department of Anatomy, Capital University of Medical Sciences
  • Received:2003-08-07 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

Abstract: The objective was to reserch on level change of SOD and MDA after traumatic brai n injur y,and on neuro-protection mechanism of Suifukang(SFK). 42 Sprague-Daleg rat s were divided into three groups: normal control group (NG), blank control group (BG), and SFK group (SG). Cerebral contusion models were prepared by weight dr opping in BG and SG rats. The injury cerebral areas were removed, and homogenize d, on 6th h, 3rd d, and 7th d after the contusion. Levels of SOD and MDA in cere bral ho mog enate were measured. Levels of MDA and SOD were distinctly higher in BG and SG (P>0.05, between BG and SG) on 6th h after cerebral contusion. Levels of MD A and S OD were distinctly higher in BG than in SG (P< 0.05) on 3rd d after cere bral contusi on. MDA content was lower in BG than in SG on 7th d after cerebral contusion (P<0.0 5). The results show that the oxygen free radical increases after cerebra l contusion, the increase is partly inhibited by treatment with SFK.

Key words: Chinese herb, SOD, cerebral con tusion, MDA

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