Abstract: The aim was to discuss the factors that might affect the quality of life of patients with advanced cancer, and to find out the social-psychological demands of advanced cancer patients.A total of 268 advanced cancer patients and their family had been systematic intervened comprehensively.Based on pain-controlling, psychological guiding and nursing instruction were provided as assistance, and the overall quality of life of the patients were evaluated.After systematic intervention, quality of life of the patients had been improved significantly.But pain in 7% patients had not been effectively controlled.In addition, fatigue, nausea, vomiting and constipation were the most common symptoms in the patients.Negative moods were more common in patients who were not aware of their actual condition than the self-aware patients.Systematic intervention can improve the quality of life in patients.But currently, pain in cancer patients has not been controlled satisfyingly.Pain and other somatic symptoms are major factors to affect the mood of patients.Medical staff should evaluate and balance the demands of patients and their family from multiple aspects, to provide better service in consolatory treatment in advanced cancer patients.

Key words: advanced cancer, quality of life, psychological guiding