Abstract:

The aim was to investigate the prognosis of fetal distress in pregnant women with hepatitis B virus(HBV) infection through analyzing the morphologic change of villus and blood vessel. ① Twenty pregnant women and their newborns were selected. The HBV surface antigen(HBsAg), e antigen(HBeAg), core antibody(HBcAb) and deoxyribonucleic acid(HBV DNA) were positive and the hepatic function normal. Eighteen pregnant women without HBV infection, normal hepatic function and their newborns were collected as control. Morphologic change of villus and blood vessel were observed.The total transverse areas and circumference of villus; the transverse area, circumference, diameter of single villus; the number of vessel in single villus and the area odds of vessel and villus were analyzed through image analysis machine. ② The incidence ratio of fetal distress in uterus was calculated. The results were: ① Comparing the investigate and the control, the total transverse areas was of insignificant difference. The total circumference was smaller than the control(P0.05). ②The transverse area, circumference and diameter of single villus of the investigate was larger than the control(P0.05). ③ The number of vessel in single villus of the investigate was more than the control. The area ratio of vessel to villus was smaller than the control(P0.05). ④ The incidence ratio of fetal distress in the investigate was 55.0%, the control was 11.1%. It suggests that the chorangiosis of placenta is caused in pregnant women by hepatitis B virus(HBV) infection, which is the main reason of fetal distress in uterus

Key words: hepatitis B, placenta, chorangiosis, fetal distress