Neural Toxicity Induced by Divalent and Tetravalent Forms of Manganese and its Protection by Selenium

Journal of Capital Medical University ›› 2005, Vol. 26 ›› Issue (6): 652-654.

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Neural Toxicity Induced by Divalent and Tetravalent Forms of Manganese and its Protection by Selenium

Chen Li¹, Wu Ping¹, Zhang Jie¹, Li Jie², Xuan Dengfeng¹, Chu Jinhua¹, Zhao Feng¹, Li Guojun¹

1. Department of Occupational and Environmental Health, School of Public Health and Family Medicine, CapitalUniversity of Medical Sciences;2. Fengtai District of Beijing Centers for Disease Prevention and Control

Received:2005-11-08 Revised:1900-01-01 Online:2005-12-24 Published:2005-12-24

Abstract

Abstract: Objective The neural toxicity induced by manganese with different valence was compared, and the protective effects of selenium was investigated.Methods The SH-SY5Ycells were divided into the following groups: control;Mn²⁺;Mn³⁺;Selenium;Mn²⁺+Selenium;Mn³⁺+Selenium.The degree of DNAstrand break was determined using a Single Cell Gel Electrophoresis method.Cell apoptosis and cell cycle distribution were determined by flow cytometry.Results Mn³⁺ induced more DNAstrand break, apoptosis and Sphase accumulation than Mn²⁺.The neural toxicity induced by either Mn³⁺ or Mn²⁺ was reduced by selenium.Conclusion Mn³⁺ exhibits stronger neural toxicity than Mn²⁺.Selenium may be a potential agent to protect neurons from Mn-induced damage.

Key words: manganese, neurotoxicity, selenium, oxidative stress

CLC Number:

R155.3⁺3

Chen Li;Wu Ping;Zhang Jie;Li Jie;Xuan Dengfeng;Chu Jinhua;Zhao Feng;Li Guojun. Neural Toxicity Induced by Divalent and Tetravalent Forms of Manganese and its Protection by Selenium[J]. Journal of Capital Medical University, 2005, 26(6): 652-654.

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Neural Toxicity Induced by Divalent and Tetravalent Forms of Manganese and its Protection by Selenium

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