Journal of Capital Medical University ›› 2006, Vol. 27 ›› Issue (1): 20-23.

• 专题报道 • Previous Articles     Next Articles

Effects of Cigarette Smoke and Ginkgo on the Expression of Transform Growth Factor-β1 in Asthmatic Rats

Lin Junling, Xu Yongjian, Zhang Zhenxiang   

  1. Institute of Respiratory Disease, Tongji Hospital, Affiliate of Tongji Medical College, Huazhong University of Science and Technology
  • Received:2005-12-16 Revised:1900-01-01 Online:2006-02-24 Published:2006-02-24

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Abstract: Objective To investigate the influence of cigarette smoke and ginkgo to the expression of transform growth factor-β1 in asthmatic rats.Methods 30 Wistar rats were divided into an asthmatic+CS group(group A),an asthmatic group(group B),an asthmatic+CS+ginkgo group(group C),an asthmatic+ginkgo group(group D) and a control group(group E).The expression of TGF-β1 of bronchial tissue in each group was observed by Western blot and reverse transcription-polymerase chain reaction(RT-PCR),respectively.Results The expression of TGF-β1 from group A and B were significantly increased compared with those of group C,D and E correspondingly and respectively(P<0.01).The expression of TGF-β1 from group D was not increased compared with those of group E(P>0.05).Conclusion CSE can increase the expression of TGF-β1 of bronchial tissue whereas ginkgo can decrease the expression of TGF-β1 of bronchial tissue in asthmatic rats.

Key words: cigarette smoke, ginkgo, asthma, transform growth factor-β1

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