Abstract:

Objective The strong relation between type 2 diabetes mellitus and overweight,obesity,obesity with acanthosis nigricans is widely concerned. In this study we determined the fasting capillary whole blood glucose(FCBG) of school children and adolescence and investigate the relation between overweight, obesity,acanthosis nigricans and FCBG further to make sure the normal level of FCBG for children and adolescence.Methods A total of 19 112 school children and adolescence from six regions of Beijing and aged 6 to 18 years were measured for height,weight,acanthosis nigricans and the FCBG,Their mean age was(12.564±3.280) years,They were divided into normal weight group,overweight group and obesity group according to body mass index(BMI)-overweight and obesity screening standard of Chinese school children and adolescence.Results The overall prevalence of overweight,obesity and acanthosis nigricans were 21.38%,9.7% and 2.43% respectively.In the group with FCBG≥5.6 mmol/L,the positive rate of overweight was 29.85%,significantly higher than that with FCBG <5.6 mmol/L 21.38%,(χ² Value=20.50,P<0.01).In the group FCBG ≥6.1 mmol/L,the positive rate of overweight was 35.92%, significantly higher than that with FCBG<6.1 mmol/L,21.31%(χ² Value=13.02,P<0.01).In the group with FCBG≥5.6 mmol/L,the positive rate of obesity was 15.99%,significantly higher than that with FCBG <5.6 mmol/L 9.54%(χ² Value=21.77,P<0.01).In the group with FCBG≥6.1 mmol/L,the positive rate of obesity was 20.39%,significantly higher than that with FCBG <6.1 mmol/L,9.64%(χ² Value=13.52,P<0.01).In the group of FCBG ≥5.6 mmol/L,the positive rate of obesity children and adolescence with acanthosis nigricans was 5.76%,significantly higher than that of FCBG <5.6 mmol/L2.43%,(χ² Value=22.5,P<0.01).The critical point 6.1mmol/L did not show any advantage when compared with the point 5.6 mmol/L.Conclusion 6～18 year old school children and adolescence with overweight,obesity and obesity with acanthosis nigricans correlated to FCBG high than 5.6 mmol/L in a much higher percentage.High risk children and adolescence for T2DM should get BG screening earlier.FCBG screening as early as possible would help prevent children and adolescence with overwight obesity and obesity with acanthosis nigricans from getting type 2 diabetes mellitus,especially for those who can not accept oral glucose tolerance test.We suggest the critical point of FCBG as 5.6 mmol/L.

Key words: overweight, obesity, acanthosis nigricans, FCBG, children