Linkage Analyses of 13q in Schizophrenia Complex Pedigrees

Journal of Capital Medical University ›› 2008, Vol. 29 ›› Issue (4): 412-415.

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Linkage Analyses of 13q in Schizophrenia Complex Pedigrees

Luo Jiong¹, Cai Zhuoji¹, Dong Fang¹, Hu Zhengmao², Jiang Tao¹, Nie Changjie¹, Huang Qing¹, Ling Sihai¹, Liu Min¹, Xia Kun², Wang Chuanyue¹

1. Beijing An Ding Hospital, Capital Medical University;2. National Laboratory of Medical Genetics of China

Received:2008-06-08 Revised:1900-01-01 Online:2008-08-24 Published:2008-08-24

Abstract

Abstract: Objective To explore the genetic susceptibility loci on 13q of schizophrenia in Chinese pedigrees.Methods 4 multiplex schizophrenia pedigrees were collected.Blood samples were collected from the families and genomic DNA was extracted.7 microsatellite markers on 13q14-13q33 were evaluated.Linkage analyses were carried out by GENEHUNTER 2.1 software.Results The results of single point-point nonparametric linkage analyses are positive at 5 consecutive locus.The NPL score are 1.40,2.25,2.06,1.71 and 1.39 at D13S156,D13S170,D13S265,D13S159,and D13S158 respectively.A 50cM positive region was observed by multipoint nonparametric linkage analyses.Positive regions were also observed by single-point and multipoint parametric linkage analyses.Conclusion Loci on 13q22.1-13q33.1 may influence susceptibility to schizophrenia.

Key words: schizophrenia, susceptibility gene, genome scan, linkage analysis

CLC Number:

R749

Luo Jiong;Cai Zhuoji;Dong Fang;Hu Zhengmao;Jiang Tao;Nie Changjie;Huang Qing;Ling Sihai;Liu Min;Xia Kun;Wang Chuanyue. Linkage Analyses of 13q in Schizophrenia Complex Pedigrees[J]. Journal of Capital Medical University, 2008, 29(4): 412-415.

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Linkage Analyses of 13q in Schizophrenia Complex Pedigrees

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