Abstract: Objective To investigate the improving effects on memory impairment of patients with schizophrenia by Si Junzi Tang.Methods 60 patients with schizophrenia treated by chlorpromazine were divided into two groups,one was treated with herb mixture named Si Junzi Tang,and the other with placebo.WAIS memory scales and PANNS were examined before and at the end of treatment.Another 30 healthy persons as control were also examined with above memory test.Results Before treatment,the score of memory item in treatment group and placebo group was obvious lower than that of normal control group(P<0.01).For score of digits forward,digits backward,number memory,figural memory,recognition,reproduction,association,comprehension,and MQ,except accumulation,obvious improvement was demonstrated in treatment group comparing with before treatment of itself and with placebo group(P<0.05).While there was no difference of each memory item score before and after treatment in placebo group(P>0.05).Conclusion Si Junzi Tang has some improving effects on memory impairment of schizophrenic patients.

Key words: schizophrenia, memory impairment, therapy with traditional chinese medicine, Si Junzi Tang