Role of Oxidative Stress in Manganese-induced Neurotoxicity

Journal of Capital Medical University ›› 2008, Vol. 29 ›› Issue (5): 664-667.

• 综述 • Previous Articles Next Articles

Role of Oxidative Stress in Manganese-induced Neurotoxicity

Zhang Jie¹, Li Jie², Wu Ping¹

1. Department of School of Public Health and Family Medicine, Capital Medical University;2. Center for Disease Control and Prevention for Fengtai of Beijing

Received:2007-04-11 Revised:1900-01-01 Online:2008-10-24 Published:2008-10-24

Abstract

Abstract: Long term exposure to manganese may induce extracorticospinal tract damage in nervous system causing Parkinson-like disease.Though the mechanism of the manganese-induced neurotoxicity is not clear,studies show that it might be associated with the oxidative stress status in vivo.This article is a review on several up-to-date researches concerning manganese-induced mitochondria damage,impacts on dopaminergic neurons and effects in Ca²⁺,Fe²⁺ion metabolism.

Key words: manganese, mitochondria damage, neurotoxicity, oxidative stress

CLC Number:

R136.3⁺1

Zhang Jie;Li Jie;Wu Ping. Role of Oxidative Stress in Manganese-induced Neurotoxicity[J]. Journal of Capital Medical University, 2008, 29(5): 664-667.

[1]	Yang Zijing, Zhao Chunli, Liang Wenqi, Chen Zhongrui, Liu Ke, Gong Shusheng. Role of mitochondrial deacetylated protein SIRT3 on the cochlea of noise-induced hidden hearing loss [J]. Journal of Capital Medical University, 2022, 43(4): 521-526.
[2]	Li Jun, Li Shuoshuo, Peng Zhixin, Liao Yajin, Cheng Jinbo, Yuan Zengqiang. Role of microglial histone deacetylases 3 in hypobaric hypoxia-induced oxidative stress [J]. Journal of Capital Medical University, 2022, 43(1): 91-98.
[3]	Li Chenchen, Xu Junmei, He Qianqian, Li Jiaying, Li Zhiheng, Xu Zhiqing, Yang Yutao. Phloretin inhibits oxidative stress response in LPS-stimulated BV2 microglia [J]. Journal of Capital Medical University, 2022, 43(1): 99-105.
[4]	Li Yanglu, Ruan Xiangyan, Cheng Jiaojiao, Zhou Qi, Du Juan, Jin Fengyu, Gu Muqing. The improved protective efficacy of combined antioxidants on cryopreserved and thawed human ovarian tissue [J]. Journal of Capital Medical University, 2021, 42(4): 526-532.
[5]	Wang Husheng, Ruan Xiangyan, Cheng Jiaojiao, Alfred O. Mueck. Study on the relationship between oxidative stress and lipid metabolism in obese women with polycystic ovary syndrome [J]. Journal of Capital Medical University, 2021, 42(4): 540-546.
[6]	Li Zhi, Zhang Jun, Dai Yuexuan, Qin Mingyang, Liang Furu. Effect and mechanism of blood glucose fluctuation on cognitive function in type 2 diabetic rats [J]. Journal of Capital Medical University, 2021, 42(3): 347-353.
[7]	Liu Ping, Lou Ke, Weng Long, Li Hui, Tang Yuling. Oxidative stress mediates the effect of NLRP3 inflammasome on chronic obstructive pulmonary disease [J]. Journal of Capital Medical University, 2020, 41(1): 131-136.
[8]	Wang Husheng, Ruan Xiangyan, Li Yanglu, Cheng Jiaojiao, Gu Muqing, Du Juan, Jin Fengyu, Alfred O. Mueck. Exploration of relationship between malondialdehyde, retinol and pathogenesis of polycystic ovary syndrome [J]. Journal of Capital Medical University, 2018, 39(4): 512-516.
[9]	Fang Yalan, Yin Jie, Liu Kejian, Zhao Yongmei. Interaction between free radicals and zinc following cerebral ischemia/reperfusion injury [J]. Journal of Capital Medical University, 2018, 39(3): 373-377.
[10]	Zheng Kaili, Wang Xiangdong, Zhang Luo. Research progress of NADPH oxidase in inflammatory diseases of respiratory tract [J]. Journal of Capital Medical University, 2018, 39(1): 69-73.
[11]	Jin He, Zhao Zhiwei, Wang Rong. Correlation between catch up growth and Alzheimer's disease [J]. Journal of Capital Medical University, 2017, 38(6): 831-834.
[12]	Shi Tingting, Yang Fangyuan, Cao Xi, Lu Jing, Xie Rongrong, Yuan Mingxia, Yang Jinkui. Angiotensin converting enzyme 2 improves insulin secretion in islets [J]. Journal of Capital Medical University, 2017, 38(2): 151-155.
[13]	Lu Jing, Sheng Han, Cheng Cheng, Song Lini, Zhang Yichen, Xie Rongrong, Yuan Mingxia, Yang Jinkui. Human ether-α-go-go related gene channels improves glucose metabolism via anti-oxidative stress in HepG2 cells [J]. Journal of Capital Medical University, 2017, 38(2): 156-160.
[14]	Zhao Yuerong, Hou Biyu, Liu Chenge, Wang Xiaobo, Du Guanhua, Zhang Li, Guan Shuyu. Effect of epalrestat on liver injury in type 2 diabetic rats [J]. Journal of Capital Medical University, 2017, 38(2): 268-276.
[15]	Yang Jian, Wang Yong, Wang Xuan, Yang Zhaofei, Gong Xiaoli, Wang Xiaomin. Parkinson's disease related gene PINK1 but not DJ-1 was down-regulated in neurotoxicity of 6-hydroxydopamine and 1-methyl-4-phenylpyridinium [J]. Journal of Capital Medical University, 2015, 36(5): 740-746.

Role of Oxidative Stress in Manganese-induced Neurotoxicity

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments