Treg Cells Depletion Can Lead to HIVspecific CD8+Cells Apoptosis in HIV Patients

Journal of Capital Medical University ›› 2011, Vol. 32 ›› Issue (2): 186-189.

• 艾滋病基础与流行病学研究 • Previous Articles Next Articles

Treg Cells Depletion Can Lead to HIVspecific CD8+Cells Apoptosis in HIV Patients

JIAO Yan-mei¹, FU Jun-liang², ZHANG Zheng², JI Yun-xia¹, WANG Rui¹, ZHANG Tong¹, CHEN De-xi¹, WU Hao^1*

1. Department of Infectious Diseases, Beijing Youan Hospital, Capital Medical University;2. Biological Centre, 302 Hospital of Chinese People’s Liberation Army

Received:1900-01-01 Revised:1900-01-01 Online:2011-04-21 Published:2011-04-21
Contact: WU Hao

Abstract

Abstract: Objective To investigate whether the decrease of CD4⁺CD25⁺FoxP3⁺ cells(Treg) can lead to HIV-specific CD8⁺ cells apoptosis in HIV patients.
Methods We characterized Tregs among 75 antiviral-naive HIV-1-infected individuals in this study. Treg and CD8⁺ cell activation and apoptosis were detected and its relevance was analyzed; Treg cells and CD8⁺ cells were simultaneously purified and then co-cultured in vitro, and HIV-specific CD8⁺ cell apoptosis was detected with pentamer and annexin V.
Results Absolute counts of circulating Treg was inversely correlated with up-regulated activation and apoptosis of CD8⁺ T cells. In addition, Tregs were found to suppress HIV peptite-induced apoptosis of HIV-specific CD8⁺ T cells. ConclusionThese findings indicate that the decrease in Tregs closely correlate with increased apoptosis of CD8⁺ T cells, especially with HIV specific CD8⁺ T cells.

Key words: regulatory T cells, human immunodeficiency virus, specific CD8⁺ cell

CLC Number:

R 512.6⁺2

JIAO Yan-mei;FU Jun-liang;ZHANG Zheng;JI Yun-xia;WANG Rui;ZHANG Tong;CHEN De-xi;WU Hao. Treg Cells Depletion Can Lead to HIVspecific CD8+Cells Apoptosis in HIV Patients[J]. Journal of Capital Medical University, 2011, 32(2): 186-189.

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Treg Cells Depletion Can Lead to HIVspecific CD8+Cells Apoptosis in HIV Patients

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