A study on the correlation between atopy and symptoms, exacerbation of patients with chronic obstructive pulmonary disease

doi:10.3969/j.issn.1006-7795.2022.04.019

Abstract

Abstract: Objective To investigate the correlation between atopy and respiratory symptoms, acute exacerbation of patients with chronic obstructive pulmonary disease (COPD). Methods There were 178 patients with stable chronic obstructive pulmonary disease from Beijing Chaoyang Hospital, Capital Medical University from January 2018 to June 2019 were collected. According to the positive serum inhalation allergen screening test, the patients were divided into atopic group (27 cases) and non-atopic group (151 cases). The demographic data, clinical symptoms and laboratory examinations of patients were collected and followed up for 12 months. The acute exacerbation of chronic obstructive pulmonary disease (AECOPD) was recorded. Results After propensity score matching,the symptoms of wheezing in the atopic group(n=27) were higher than those in the non-atopic group(n=77) (77.78% vs 55.84%). The difference was statistically significant (P=0.044). The total serum immunoglobulin(IgE) level in the atopic group was significantly higher than that in the non-atopic group, and the value of forced expiratory volume in first second(FEV1 )was also significantly higher than that in the non-atopic group (P<0.001,P=0.019). Following up for 12 months, the frequency of frequent severe acute exacerbations in the atopic group was significantly higher than that in the non-atopic group (29.63% vs 10.39%), and the difference was statistically significant (P=0.038). Conclusions Atopy can lead to the increase of wheezing symptoms, severe and frequent acute exacerbations in patients with COPD.

Key words: chronic obstructive pulmonary disease (COPD), atopy, symptoms, acute exacerbation

CLC Number:

R563

Zhou Yuyan, Chen Xiaoting, Wang Wanying, Li Jing, li Deshuai, Bu Xiaoning. A study on the correlation between atopy and symptoms, exacerbation of patients with chronic obstructive pulmonary disease[J]. Journal of Capital Medical University, 2022, 43(4): 635-640.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.04.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I4/635

References

[1] Justiz Vaillant A A, Modi P, Jan A. Atopy[M]. Treasure Island: StatPearls Publishing, 2022.
[2] Veil-Picard M, Soumagne T, Vongthilath R, et al. Is atopy a risk indicator of chronic obstructive pulmonary disease in dairy farmers?[J]. Respir Res, 2019, 20(1):124.
[3] Jamieson D B, Matsui E C, Belli A, et al. Effects of allergic phenotype on respiratory symptoms and exacerbations in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2013, 188(2):187－192.
[4] Suzuki M, Makita H, Konno S, et al. Asthma-like features and clinical course of chronic obstructive pulmonary disease. an analysis from the Hokkaido COPD cohort study[J]. Am J Respir Crit Care Med, 2016, 194(11):1358－1365.
[5] Vogelmeier C F, Criner G J, Martinez F J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. Gold executive summary[J]. Am J Respir Crit Care Med, 2017, 195(5):557－582.
[6] Bafadhel M, McKenna S, Agbetile J, et al. Aspergillus fumigatus during stable state and exacerbations of COPD[J]. Eur Respir J, 2014, 43(1):64－71.
[7] 慢性阻塞性肺疾病急性加重(AECOPD)诊治专家组.慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2017年更新版)[J]. 国际呼吸杂志, 2017, 37(14):1041－1057.
[8] Dispenza M C. Classification of hypersensitivity reactions[J]. Allergy Asthma Proc, 2019, 40(6):470－473.
[9] Ring J. History of allergy: clinical descriptions, pathophysiology, and treatment[J]. Handb Exp Pharmacol, 2022, 268: 3－19.
[10] Musafiri S, van Meerbeeck J, Musango L, et al. Prevalence of atopy, asthma and COPD in an urban and a rural area of an African country[J]. Respir Med, 2011, 105(11):1596－1605.
[11] Awopeju O F, Salami O T, Adetiloye A, et al. The relationship between asthma control and health-related quality of life in asthma and the role of atopy: a cross-sectional study of Nigerian adult asthmatics[J]. Pan Afr Med J, 2021, 38: 393.
[12] Karakioulaki M, Papakonstantinou E, Goulas A, et al. The role of atopy in COPD and asthma[J]. Front Med (Lausanne), 2021, 8: 674742.
[13] Fattahi F, ten Hacken N H T, Löfdahl C G, et al. Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study[J]. Respir Res, 2013, 14(1):10.
[14] Neves M C L C, Neves Y C S, Mendes C M C, et al. Evaluation of atopy in patients with COPD[J]. J Bras Pneumol, 2013, 39(3):296－305.
[15] Vroling A B, Duinsbergen D, Fokkens W J, et al. Allergen induced gene expression of airway epithelial cells shows a possible role for TNF-α[J]. Allergy, 2007, 62(11):1310－1319.
[16] Tsai J J, Liao E C, Hsu J Y, et al. The differences of eosinophil-and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease[J]. J Asthma, 2010, 47(9):1040－1044.
[17] Hogea S P, Tudorache E, Fildan A P, et al. Risk factors of chronic obstructive pulmonary disease exacerbations[J]. Clin Respir J, 2020, 14(3):183－197.
[18] Zhou A Y, Zhou Z J, Zhao Y Y, et al. The recent advances of phenotypes in acute exacerbations of COPD[J]. Int J Chron Obstruct Pulmon Dis, 2017, 12: 1009－1018.